Avengers 4: 10 Most Likely Characters To Be Killed
3. Drax
Drax and Thanos have a lot of unfinished business, and while he's been reimagined as a comedy figure, he still wears the wounds of his family's death at Thanos' hands very close to the surface. When he gets wind of Thanos making a play to threaten the entire galaxy, we can expect him to go back to being the berserker he was in the first Guardians movie.
He's also a fairly big threat to Thanos before he manages to fully empower himself and their personal history (on top of Drax's impulsiveness) will probably bring them into close proximity. And that's definitely bad news for Drax, who could lay down his life for his friends (the new family he's craved without realising it) and be reunited with his real family.
Quite who would turn up to his funeral remains to be seen, but the part of the casting call mentioning the need for actors who look interesting might suggest they aren't all going to be human.