Avengers: Infinity War - Predicting The Entire Plot In 20 Steps
19. Introducing The Underground Avengers
Whether this actually happens as the prologue (or part of it) remains to be seen, but there has to be a sequence that establishes what Steve Rogers (now possibly going by the name Nomad), Scarlet Witch and Falcon have been up to since the end of Captain America: Civil War.
The suggestion is that they've effectively been operating as a sort of Secret Avengers team (a character bio released by Toys R Us confirmed that Cap has been undertaking "clandestine"), taking down what remains of the enemies of SHIELD. A cast listing for The Winter Soldier actor Callan Mulvey suggests he's returning as HYDRA agent Jack Rollins, which would seemingly confirm that we'll get at least one set-piece involving the new "Nomad" team cleaning up some loose ends.
There is, of course, the chance that we'll get this as a sort of establishing flash-back later in the movie, but having it kick things off would fit Marvel's usual approach to prologues.