20 Video Game Bosses You Must Defeat Before You Die

16. Mike Tyson (Mike Tyson's Punch-Out!!)

Frequently hailed as one of the most challenging boss fights in video game history, the final opponent in Mike Tyson's Punch-Out!! is, inexplicably, Tyson himself, a hulking beast of a man with a record of 99-0 (all knockouts), who will most likely make mince meat out of you the first 20 times you play this match. The key to beating Tyson is that it's all about patience and reflexes, especially during the start of the match, in which Tyson flings his signature Dynamite Punches at you in an attempt to quickly bring the match to a close. Though most of Tyson's attacks can be anticipated by a visual cue, sometimes he'll just jab you out of nowhere, so it's best to both keep on the move and keep dodging while getting jabs in where possible. Eventually, this approach will knock Tyson out, or you can hope for a win by decision, but either way, you'll probably have smashed your way through a few controllers first.