2. Dr. Otto Octavius/Doctor Octopus
In this game, Doc Ock is perhaps even more human than his interpretation in Sam Raimi's Spider-Man 2. In both cases, Otto acts as a mentor to Peter in some form, experiences tragedy, and is driven mad by the technology that allows him to operate his mechanical limbs.
But where Insomniac trump the live action film is in the slow build and depth of character that they can afford without the time restraints of a Hollywood blockbuster. Otto is much more likeable and takes a much bigger role as a mentor in Peter's story here, and his intentions are very humanitarian and admirable. He even helps create a better Spider-Man costume in the early stages of the story.
And when his past with Norman Osborn is revealed, and his present circumstances change, the build to his insanity feels far more organic and natural than the sudden turn in the Raimi film.