To those who are casual boxing fans, Floyd Mayweather Jr. is probably the guy you associate with being Manny Pacquiao's biggest nemesis. However, to those who have followed the sport, and 'Pac-man' for years, you'll know that it's actually Mexican heavy-hitter Juan Manuel Marquez who will go down in history as the Filipino's biggest foe. Their rivalry spanned eight years, four punishing scraps, two different weight classes and one brutal knockout. Although Marquez has drawn once and lost twice to Pacquiao, he had the last laugh when he brutally knocked the 36-year-old out with a crushing right to the jaw in the sixth round of their last fight in 2012. https://www.youtube.com/watch?v=SOXbYeeQMfA