5. Chelsea Handler (Herself - Chelsea Lately)
It's not just in acting roles that women are excelling in, since 2007 Chelsea Handler has been at the reins of her own talk show, Chelsea Lately, which airs five nights a week on the E! network. Presently Chelsea is the only female host of a late-night talk show in America, an impressive feat in itself. She has become known for her unique sense of humour and the straight-talking approach she takes when interviewing her guests. No punches are pulled no matter how A-list the star she might be talking to, which is what makes Chelsea Lately such compelling, and hilarious, viewing. Her comedy monologues are also what makes the show so great, shutting up any critics who argue that the reason there are so few female standup comedians is because women aren't funny once and for all.