1. Serena's Confession
The ultimate OMFG moment. The final minute of Episode 1x16 launched Gossip Girl from the average teen show into a cultural phenomenon. After almost two full episodes of trying to avoid Georgina and her many blackmail attempts, Serena breaks down in front of Blair on the steps of the Waldorf penthouse. The music crescendoes and Blair coaxes the three-word confession from Serena, "I killed someone." Delivered expertly by Blake Lively and brilliantly set to an instrumental of The Kills' "URA Fever," Serena's admission of guilt remains the shows most iconic and memorable moment. Honorable OMG moments: Serena and Nate's past revealed in the pilot episode. Georgina befriends Dan and calls herself Sarah. Blair being traded by Chuck for a hotel. The Threesome between Dan, Vanessa, and Lizzie McGuire. Jenny and Chuck get it on. Blair kisses Dan. Georgina's pregnancy. Lily having Serena arrested. Georgina proclaiming, "You can tell Jesus 'the bitch is back.'"