7 Hints That Cersei Will Die On Game Of Thrones

At the end of Season 5, we saw Sansa and Theon jump off of a tower at Winterfell into a pile of snow: ok so we didn't see them stick landing but off screen death is never proper death.

Sansa has a lot of rage built up inside her having been through a lot. Placing the entire horrific Ramsay debacle aside for a moment, the Lannisters have completely destroyed all the things she held dear. She was forced to be Joffrey's toy to torture and abuse, then they married her off to Tyrion for their own pleasure and are solely responsible for killing a huge chunk of her family, including both of her parents. 

Girlfriend has a score to settle. 

Cersei would likely be the main target of Sansa's hell fury and if the aforementioned prophecy of a "younger, more beautiful" queen coming to take all that Cersei holds dear is true, Sansa could be another candidate to fulfil it if Margaery doesn't.

Sansa is beautiful, younger and certainly would relish to destroy all that Cersei holds dear. Not to mention the fact that Jamie and Brienne still swore an oath to Catelyn, which Jamie's actions up until this point seem to suggest he intends to keep. This would put Jamie in quite the predicament given his already tenuous relationship with his sister/lover since he returned to Kings Landing sans sword hand. 

Being betrayed by Jamie would be a huge blow to Cersei, especially on top of her children's deaths, and could be the final straw that breaks her back.