1. Laverne & Shirley
Laverne & Shirley was always about the two gal pals in the title, and also Lenny and Squiggy and other such characters. For the vast majority of the shows run, the two worked as bottle cappers at a beer brewery in Milwaukee. However, for the sixth season, the show decided to pick up and move to Burbank, California. There, they got jobs as gift wrappers, which makes sense. What makes less sense is that all their friends and family decide to move with them. The show went under one more, somewhat significant tweak for the final season. You know, just the loss of one of the main characters. Cindy Williams, who played Shirley, was pregnant, and decided not to return, even though her name remained in the title. The show couldnt survive without Shirley, and somewhat inexplicably, the series finale was a backdoor pilot for a show that never came to fruition.