This much loved Holmes story features a missing racehorse, a murdered trainer and a drugged curry. It is best known, though, for what Holmes considers: "the curious incident of the dog in the night-time", that the guard dog did not react when the horse was taken, proving the criminal was someone familiar to it CBS' Sherlock-alike Elementary has already used a similar incident of a guard dog's failure to react as a vital clue in one of its episodes, so something similar in the BBC show is quite plausible. However, given the Gatiss-Moffat love of replacing the Victorian elements with modern technology (H.O.U.N.D. for the Baskerville's hound, for example), an issue with a complex, high-tech alarm system not functioning is probably more likely. As to the main details of the plot, they involve attempts to cripple the champion horse of the title by slicing into its leg with a cataract knife and to disguise it as a different horse by dying its distinctive white markings. The initial main suspect is a bookie. Given betting and sports betting in particular is bigger money than ever and, thus, open to fixing by international criminal gangs, a gambling corruption story would fit the contemporary setting. It wouldn't even have to be about horse racing: look at all the recent football gambling, match fixing stories.