Supernatural: 20 Greatest Music Moments

10. "Do You Love Me?" By The Contours (5.4, "The End")

When Zachariah decides to send Dean forward to a future in which he did not help the angels, Dean wakes in the year 2014 (uh-oh?). Finding himself in an abandoned city, he wanders around until he finds the word "CROATOAN" graffitied on a building. A post-apocalyptic setting combined with Croatoan--a disease that causes uncontrollable murderous rage--does not bode well for Dean. Right on cue, a mob of infected people appears and chases Dean down the empty streets, ala 28 Days Later. Running full-out, Dean finds himself trapped between a blockade and the mob. Suddenly, soldiers appear from behind the blockade and open fire on the diseased pursuers. "Do You Love Me?" blasts out of the speakers of a Humvee. It's pretty cool.

9. "O Death" By Jen Titus (5.21, "Two Minutes To Midnight")

In "Two Minutes To Midnight," as the Apocalypse looms closer and a storm gathers over the Midwest, we get the coolest character introduction this side of the angel Castiel. To the sound of a haunting Jen Titus rendition of "O Death," Death himself emerges from a white 1959 Cadillac. Swinging a cane, he saunters down a Chicago street. An inconsiderate businessman bumps into him as he passes. "Hey, watch where you're walking, pal," the man spits, not once looking up from his cell phone. Death pauses for a moment, brushes off the shoulder of his coat, and glances back at the businessman, who suddenly clutches his heart and collapses. Death resumes walking, and we never see his face beyond a profile. This is why you don't walk and text, kids.

The Introduction of Death: