The Snowmen
The Doctor has moments of contempt for humanity, but overall he cares for us deeply. Thats why it was so painful to see him withdraw from humanity and the rest of the universe in The Snowmen. In the episodes prequel, he refuses to engage with any of the mysteries and adventures offered to him: he no longer cares about people. He lives removed from humanity on top of a cloud, reachable only by an invisible staircase. He meets no one new: that staircase can only be found by someone who knows what theyre looking for. In the first half of the episode, the Doctor repeatedly rebuffs everyone who talks to him, even trying to erase Claras memory of him. When Strax resists his apathy, the Doctor says over a thousand years of saving the universe, you want to know the one thing I learned? The universe doesnt care.
And that there is the essential problem of humanism: the universe doesnt care about us, no divine entity cares for us. The world doesnt owe us anything. That didnt stop the Doctor from trying to bargain with the universe, though. Desperate to save Clara and knowing its hopeless, the Doctor and Vastra have the following exchange:
Are you making a bargain with the universe? Youll save the world to let her live? Yes. And dont you think, after all this time and after everything I have ever done, that I am owed this one? I dont think the universe makes bargains.
But Clara dies anyway, because the universe doesnt care.