WWE Wellness Policy - 6 Wrestlers Badly Derailed (And 4 That Prevailed)

Though not directly thrown off course in ways other on this list may have experienced, the damage done to Mysterio's credibility and status as a children's superhero went deeper, appearing to sever ties between performer and company permanently.

First caught out as one of the numerous names linked to the 2007 Signature Pharmacy scandal (which found the Orlando-based locale busted on multiple counts of Steroid and Human Growth Hormone distribution), he then copped for suspensions in 2009 and 2012, each time chipping away at a legacy and mystique WWE has failed to recreate with others in his absence.

Quite literally masking his age and increasing frailty, the nature of his character often hid a litany of injuries that piled up on his diminutive frame, which certain supplements must have aided after a lifetime on the road.

But the realities of his reliance on these seemed to furnish a mutual disinterest between WWE and Rey himself. Younger fans had John Cena to follow instead, and older ones abandoned him outright, shown infamously when he became the innocent victim of WWE's refusal to enter Daniel Bryan in the 2014 Royal Rumble. Booed mercilessly, he was the Number 30 entrant that closed the door on the possibility of a Bryan win.

He'd never work again with WWE after April of that year, arguing his way out the door with rows about unwanted contract extensions. It was an unfitting end to his tenure, but one that sadly felt a long time coming.