10 Most Powerful Characters Killed By The Punisher
7. Venom
The Punisher has managed to kill Venom at least two times in various realities of the Marvel Universe. He killed him (along with everyone else) in The Punisher Kills The Marvel Universe, and he had a chance to take on the symbiote once more in Marvel Universe vs. The Punisher.
In that story, it's the Marvel Universe out to get Frank Castle, and Venom was working with Spider-Man. Interestingly, at this point in the story, the reader is led to believe that Spider-Man is the primary antagonist, but it quickly becomes clear that Spidey isn't the character people need to fear.
When Venom went up against the Punisher, they got to beating on one another quickly, but Frank had a trick up his sleeve in the form of a pistol that shot out a sonic blast. During their fight, he pulled out the sonic pistol and aimed it squarely at Venom.
Seeing he was at a disadvantage, Venom attempted to reason with the Punisher, but Frank wasn't willing to listen to anything Venom had to say. Without another word, the Punisher pulled the trigger, killing both the Venom symbiote and its host.