4. Rosanna Arquette Or Patricia Arquette Vs David Arquette
Basically, you can have your pick here. Rosanna Arquette has been working regularly since the 1980s, best known for her roles in Desperately Seeking Susan and Pulp Fiction, while sister Patricia blew us all away in True Romance, and shot to considerable fame as the star of the TV show Medium, which has earned her 3 Golden Globe nominations to date. Brother David Arquette, on the other hand, is best known for playing Dewey in the Scream series (admittedly an awesome role), being formerly married to Courtney Cox, and...winning the WCW Title, making wrestling fans the world over completely irate. He still works consistently, but hasn't had a significant role outside of the Scream series in years. And probably rightly so.