9. Estrogen Poisoning - The Other Woman
20th Century Fox
The Scene: When Carly (Cameron Diaz) finds out that her partner Mark (Nikolaj Coster-Waldau) is married, she teams up with Mark's wife Kate (Leslie Mann) and Mark's third woman, Amber (Kate Upton), to get revenge on the suave creep. One of their first schemes involves mixing estrogen into his smoothies, which causes Mark to appear to grow breasts (complete with giant nipples) and suffer from impotence.
Why It Sucks: Tonally, this scene is just way out of whack. Sorry, but altering someone's body chemistry isn't just unfunny, it's also pretty dangerous, and we can only imagine that were gender roles reversed in this situation, the scene would have been wildly controversial, deemed creepy and sick. While we're totally down with the girls' revenge scheme to begin with, this scene pretty much kills it dead: how can we get behind such unlikeable and irresponsible people? Mark may have been an a**hole, but that doesn't mean you need to poison the guy. Jesus.