4. Victor Zokas aka Renard The World Is Not Enough
Renard is a KGB agent turned terrorist which makes it pretty unwise to mess with him. But what makes him so scary - aside from Robert Carlyle's unsettling performance - is that he is impervious to pain because, following a previous attempt on his life by MI6 he has a bullet lodged in his brain. Of all the Bond villains there have been over the years, Renard was one of the most serious and intimidating. He delights in the pain of others because he can't feel anything himself. In one unpleasant scene he watches gleefully as he forces a man to hold a searing hot coal, unable to feel it on his own hand because of his condition. Renard is one of the scariest bond villains, principally because nobody could hurt him. His pain-immunity could not however protect him from the plutonium road that eventually impales and kills him.
Maybe 009 should have killed him that way in the first place and saved 007 the trouble. Shooting people in the head is so unreliable...