4. Gwen Stacey
Fans of the comics will know that Gwen Stacey's story doesn't end pretty. The end of the film shows Peter and Gwen pretty much back together even though he told her dying father she would stay away for her own safety. If you don't read the comics, then you know that (MAJOR SPOILER) Gwen is killed by the Green Goblin after he discovers her relationship with Spider-man/Peter Parker. I really hope the sequel goes in this direction seeing as it was perfectly set up by Gwen's father in this film. I mean, how gut-wrenching would that whole sequence be? And how much depth would it add to Peter's character?