Marvel's Loki TV Series: Everything We Know
2. The Story Will Follow Loki Through Human History
There's been some speculation that Loki managed to survive his apparent demise at the hands (or rather, hand) of Thanos, since the trickster has been known to evade certain death on more than one occasion.
However, it really does seem like this is the end for the character - at least in the movies. Not only did Infinity War's directors respond to the "Bruce Banner is actually Loki" theory by saying "Loki is dead", but the basic outline of his Disney Plus show is another hint that the character doesn't have a future.
Heading back to that THR report once more, sources for the site claim that the show will follow Loki as he pops up throughout human history as an "unlikely influencer on historical events." To put that another way, the show will be a prequel to the present-day MCU continuity, so Loki can stay dead and the series will still work.
No specific historical events were mentioned, but since Asgardians can live for thousands of years, the writers have a boatload of interesting time periods to play with.