5. John Malkovich - Vulture
Just because Sam Raimi wasn't able to make his own casting choice for the Vulture, that shouldn't mean the new Spider-Man series cannot follow the same line of thought. He might be advancing in years now, but that doesn't mean Sam Raimi's choice for the Vulture wouldn't still be a good choice for the character, particularly given the fact that the most famous Vulture - Adrian Toomes - was an elderly man whose powers (offered by the harness that allows him to fly) have extended his life span, and made him resistant to injury. It might seem like empty sentiment, but franchises like Spider-Man can still profit from fan service casting choices like this, and Malkovich's potential casting for Raimi's ultimately unrealised fourth Spider-Man movie did hit well with fans. He is the perfect blend of theatricality and threat - see his performances as Cyrus The Virus and Mitch Leary in In The Line Of Fire - with a classical feel to his presence, and a similar intangible anti-charm that worked so well for Willem Dafoe as the Green Goblin in Raimi's series. Raimi didn't cast badly - even Topher Grace wasn't a bad choice for Eddie Brock - and fans would no doubt respond well to his original casting plan for the Vulture coming to fruition.