Spider-Man: Far From Home - What The Title Means
3. He Loses Sight Of What His Real Responsibilities Are
Since Spider-Man: Far From Home is going to be released months after Avengers 4 and will apparently take up Peter's story JUST after the end of the narrative, it's likely it will be heavily invested in the fallout of the Infinity Saga.
We already saw in Homecoming how difficult Peter found adjusting to "normal" life after being involved in the Cvil War events and that's nothing compared to what happened in Infinity War. In other words, there's going to be major ramifications for Peter and it makes sense that he will struggle.
How he'll readjust to taking down muggers and bike thieves when he was fighting for the very survival of the universe is up for serious debate. And it could well be that he loses sight of what his spiritual home - being a friendly neighbourhood Spider-Man who balances studying with heroism - should be.
He could literally end up lost and have to find his way back home through the events of the movie.