9. The Binding Of Isaac
This won't be the only time that a game created by Edmund McMillen appears on this list - that dude sure does know how to create something that makes players feel visceral, primordial disgust.
One such game is his legendary 2011 roguelike The Binding of Isaac, which is filled to the brim with deeply offputting imagery, from penile and feces-based enemies to a dominant aesthetic defined by only the most soul-crushingly dreary browns and reds.
While it's fair to say that the original Flash version of the game was basically ugly out of necessity, the slicker 2014 remake, The Binding of Isaac: Rebirth, nevertheless retains that holistic original art style, which is 100% consistent with the game's darkly transgressive themes and ideas.
The Binding of Isaac's wilful desire to disgust won't be for everyone, and that's fine, but beneath its deeply grotty visage is one of the greatest roguelikes ever made.