100 Things You Never Knew About Resident Evil
88. She's A Man Killer
Between the 1996 version of Resident Evil and it's 2002 remake, several aspects of the lore were changed. Largely, these were things that happened more off-screen like world-building info. Several BOWs got slightly tweaked backstories, and one of these were the fearsome Hunters.
In the original game, there was an allusion to Umbrella kidnapping the homeless to use as a test subjects. However, as dark as this was, it implied that BOW creation was an exact, repeatable science and that different people would always become viable weapons which doesn't gel with the idea of framing Umbrella as "mad science".
In the remake, it's much more interesting and decidedly more disgusting. In attempt to make more animal-based weapons but with an increased intelligence, William Birkin decided that DNA splicing was needed. As such, Umbrella infected a pregnant woman's embryo with the t-Virus as well as reptilian DNA. She gave birth to the first Hunter, which was then mass-produced.
So every Hunter alpha that stalks the Spencer Mansion was born from a human woman and, due to the cloning process, are all female.
So the next time one takes your head clean off, you know which gendered swear words to use, I suppose.