10 Times The Lucifer Show Referenced The Comics (And 10 Ways It Totally Ignored Them)
5. Lucifer's Kryptonite (Ignores The Comics)
In the TV show, one major plot element revolves around Lucifer being immortal and invulnerable to damage... except when Chloe Decker is nearby. In the comics, Chloe doesn't exist, and Lucifer has no "kryptonite" or weakness of any kind.
The comic version of Lucifer is one of the most powerful entities in any work of fiction in history. In DC's power hierarchy he's second only to Yahweh, and rivaled only by his brother, Michael, and there is no person or substance that can diminish his power the way we see Chloe do on the show.
There are certainly ways to injure, or even kill Lucifer in the comics - and of course his enemies come close to destroying him at times - but there's no easy trick to it, like simply attacking when he's with a certain person. Mike Carey, and the antagonists he wrote, had to be much more creative and artful than that in their efforts to dethrone the Morningstar.