3. Spider-WomanFirst off nothing to do with Spider-Man. Secondly, we're talking about the Jessica Drew version. The characters of Drew and Skye do have several things in common, and there are other elements within the Agents of S.H.I.E.L.D. series that fans have suggested would link the two together as potentially being the same character as well. Both were given an experimental serum to save their lives, although in Drew's case it was as a result of uranium poisoning, while with Skye it was after she was shot. Admittedly Drew's origin was then re-written to be the result of a laser beam, but the producers might have chosen to ignore that. Drew's original origins include references to the High Evolutionary a character whose powers fits the mould of the Clairvoyant within the show and would be massively interested in the process which saved Coulson's life. Both of the characters have been linked to other organisations at one point or another, with Skye's involvement in the Rising Tide, while Drew was working with HYDRA (intended as a double-double-agent) although it turned out to be a trap led by the Skrulls. Drew was also a member of S.H.I.E.L.D. and an agent for some time, and has an ongoing working relationship with Nick Fury as well as occasionally being a member of the Avengers and S.W.O.R.D. The power set that Spider-Woman has wouldn't be outside of the realm of television she can emit venom blasts, occasionally fly, has special pheromones and most importantly is good in combat with her enhanced strength, speed and stamina. But revealing Skye as Spider-Woman might be a little clumsy, and it doesn't fit with Skye's 084 designation as a baby at all.