Game Of Thrones: 7 Most Likely Winners & Losers Of Season 6
1. The Boltons

Likely Outcome: Defeated, flayed... All manner of terrible things, hopefully.
If Jon Snow actually does return by the end of the season, his revival will be the worst news possible for the Boltonscurrently making house in his family home.
But even if he doesn't ride back into battle in the knick of time to vanquish his sister's tormentor, the rally of the families loyal to the Starks with the Wildlings and the Tullys The battle at Westeros cannot end in any way other than with the Boltons falling, even if (or when, more likely) the Freys arrive to bolster their ally's forces.
Ramsay himself may endure to personally hunt Sansa and Reek, but that story will actually improve if his House has already fallen. And the idea of him being even more desperate and disgusting (like going after Rickon, for instance to draw out his prey) seems chillingly pertinent. Hopefully he will still die by the end though.
And now on to the likely winners...