The X-Files: 15 Guest Stars Who Made It Big

5. Shia Labeouf (Season 7, Episode 6: The Goldberg Variation)

On The X-Files: Originally airing on December 12, 1999, The Goldberg Variation sees Mulder and Scully drawn into a series of unlikely events that all seem to centre around the lucky streak of Mr. Henry Weems. Shia LaBeouf plays Richie Lupone, a young boy in need of a liver transplant. Most Memorable Moment: Richie notices that Mulder never mastered the philosophy of "righty tighty, lefty loosey." How Shia LaBeouf Made It Big: Only thirteen years old when he filmed The Goldberg Variation, LaBeouf would go on to star as Louis Stevens on The Disney Channel's Even Stevens from 2000 - 2003, then hit the silver screen with the lead role in Holes in 2003. In 2007, he headlined the first of his three Transformers films before moving on to play the son of Indy himself in 2008's Indiana Jones And The Kingdom Of The Crystal Skull. He's not famous any more, though.