10 Biggest Catastrophes In DC Comics
2. Flashpoint
As far as elaborate timeline manoeuvring goes, there are few events that can match that of Flashpoint. With the premise essentially being that the Flash's toying around in the past has endangered the 'main' DC universe, the series covers the threat of both the new universe that Barry Allen has unknowingly created, and also the threat of his 'home' universe being permanently destroyed due to the hero's actions.
Given that the new universe Barry makes has an extra thirty-five thousand people die because of Superman's ship crashing in a slightly different place, it seems safe to say that this marks a pretty considerable catastrophe - even without the added knowledge that, yet again, the world almost ended.
Even the solution to this crisis ends in a pretty cataclysmic way, as in order to save the millions that died in the alternate universe, the Flash has to leave it in the middle of what appears to be a world-ending event.
While the return of that universe's Thomas Wayne in the Batman series may suggest this ultimately didn't end the world, for now it appears as though everyone who existed in that timeline was destroyed at the end of Flashpoint, which gives the event a hefty death toll.