Luthor works best when he isn't being a full-blown supervillain. The true genius of the man who tries time and again to destroy Superman is that he does it whilst still seeming like an okay guy to the world at large; most of the time he justifies his actions as a way to defend humanity about the threat of alien invasion (Clark Kent being from Krypton and all), or else he manages to spin any of his encounters with the Man Of Steel so they both come out smelling of roses. Seeing the hoops he leaps through to act like a supervillain but never get accused of being one some writers will have him acting entirely civil and sane with everyone except Superman, furthering the illusion is part of what's interesting about the character, what elevates him to a higher plane than your average comic book antagonist. The Legion Of Doom is totally antithetical to that idea. Eisenberg is going to be a more complex version of the character (presumably) than the guy who leads The Legion Of Doom, the evil counterpoint to the Justice League and hangs out with irredeemably bad people like Braniac, Sinestro and Captain Cold.
Tom Baker is the Comics Editor at WhatCulture! He's heard all the Doctor Who jokes, but not many about Randall and Hopkirk. He also blogs at http://communibearsilostate.wordpress.com/