10 Villains Spider-Man Has NEVER Defeated
4. Nebula
Nebula's constantly flip flopping status in the Marvel universe can make it hard to trace when any hero fought her, but fortunately Spidey's one and only time going toe to toe with the daughter of Thanos comes in one of Marvel's most famous events: The Infinity Gauntlet.
When Nebula steals the infinity gauntlet from Thanos, the power gained from taking the gauntlet and all the gems all at once drives her completely insane. So Adam Warlock grabs all the heroes that had been brought back by Nebula using the gauntlet in a moment of genuine sanity to try and get it back from her.
Yeah, as you can probably surmise, when The Hulk, Thor, Drax The Destroyer, and Doctor Strange can't really touch Nebula, Spider-Man doesn't stand a much better chance.
Since then, Nebula has been drifting further and further to the side of good, thanks in large part to her appearances in the MCU, so it's unlikely that she and Spidey will be having a rematch anytime soon. A technicality, sure, but one that still lands her solidly on this list.