55. The Mandarin
FIRST APPEARANCE: TALES OF SUSPENSE #50 (1964) The Mandarin was born in China to a wealthy family, which only helped him to develop into a megalomaniac as an adult, though retaining some sense of honour throughout his countless battles with Iron Man. Not only an incredibly astute scientist, he is also a superbly adept martial artist, but his main distinguishing attribute is the ten rings of power that he wears on his hands, each one containing a very specific, individual power which he transferred from a crashed alien spaceship. The Mandarin has spent decades toughening his own body for combat, to the point that his attacks can split Iron Man's armour, and can use his life force (aka "chi") to sustain himself for years without food or water. He is an expert on alien technology in addition, allowing him to use the ten rings to provide ice, electro and flame blasts, as well as light attacks, various force beams, and even one which can rearrange any matter it is aimed at. He is, however, also a man of his word, and sticks fiercely to any promises he makes about the conditions of combat. Sadly, very little of this was conveyed in the bizarre Iron Man 3 version of the character, played by Ben Kingsley.
54. Apocalypse
FIRST APPEARANCE: X-FACTOR #6 (1986) Villain names don't get a whole lot more badass than Apocalypse, an ancient Egyptian mutant who is able to control ever single molecule in his body, bending it to his every will, allowing him to adapt to extremely harsh environments, recover from traumatic injuries, bestow himself with pretty much any superpower known to man, and even transform himself into complex shapes, such as vehicles and weapons. Essentially, Apocalypse is immortal, able to recover from any injury he sustains, and never aging. In addition, he is extremely intelligent, with an expert understanding of the sciences, as well as being a technopath, able to interact directly with technology, not requiring a medium through which to deal with it. Perhaps the most important factor of all, though, is that his blood can heal any fellow mutants, though will prove near-instantly fatal to any human beings it comes in contact with.
53. Carnage
FIRST APPEARANCE: THE AMAZING SPIDER-MAN #344 (1991) It's no coincidence that Carnage so closely resembles Venom (and that's why we've not seen him in a movie yet, despite being a fan favourite villain), because he was originally designed to be a darker replacement for the character. He is created when serial killer Cletus Kasady is sent to prison, and comes into contact with the offspring of Eddie Brock aka Venom's symbiote, transforming him into Carnage, essentially a more violent, sadistic and amoral version of his predecessor, to the point that Spider-Man had to enlist Venom's help to take him down. Carnage possesses many of Spidey's attributes, such as clinging to walls, the Spidey sense and web-slinging, but can also fire weapons from the symbiote and bend its every attribute to his well, even creating a tendril to implant ideas in people's minds. His main known weaknesses are, like Venom, sound and intense heat.