10 Hardest Bosses In Resident Evil History

1. T-078 - Resident Evil: Code Veronica

Resident Evil Mutated Wesker
Capcom

At first glance, The T-078 doesn't seem any more threatening than any other inclusion on this list, but we can assure you that no other boss in Resident Evil's history has caused so many first-time players to throw in the towel.

Not only is this Tyrant-variant a hyper-aggressive, damage sponge that you must fight in an aircraft's confined cargo bay, but you also run the risk of falling out of the exposed hatch. You also can't rely on bullets to defeat him. The only way to successfully win is to knock him out of the plane using a rigged-up cargo crate, once you've weakened him enough.

All of that amounts to an incredibly challenging fight, but there's one extra little detail that pushes it over the edge.

The T-078 has an incredibly large health-pool, meaning you need a lot of firepower in your inventory to take him down. If you reach this section of the game and you're underpowered, you stand no chance of winning.

And if you're one of the unfortunates who didn't have enough ammo and decided to save directly before entering the boss room, you cannot progress and have no choice but to start the whole game again.

Seriously, screw this guy!

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UK based screenwriter, actor and one-half of the always-irreverent Kino Inferno podcast. Purveyor of cult cinema, survival horror games and low-rent slasher films.