10 Hardest Bosses In Resident Evil History

2. Nemesis (Clock Tower Battle) - Resident Evil 3

Resident Evil Mutated Wesker
Capcom

Generally speaking, any encounter with this staple-faced creep could have qualified for this list, but we've got to give it to the skirmish outside the clock tower for being the most hellishly difficult.

Unlike all of your previous encounters with Nemesis where you could outrun him, this one is mandatory and escape is impossible. You're confined to a small courtyard with no choice but to throw everything you've got at him because that's exactly what's he going to do to you.

Nemesis is arguably at his most aggressive here and will not allow you any time to breathe. Your only hopes of beating him are to have a decent amount of grenade launcher and magnum ammo, as well as a keen grasp of the game's somewhat unreliable dodge mechanic. Even with those helpful additions, you'll still be hoping and praying that each shot you fire will be the one to take him down.

You can make this fight a little easier by making the correct choices earlier in the game, which will result in Nemesis not having his rocket launcher for the fight, but even with that extra advantage, you're in for one hell of a fight.

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UK based screenwriter, actor and one-half of the always-irreverent Kino Inferno podcast. Purveyor of cult cinema, survival horror games and low-rent slasher films.