4. Her Best Friend Is Her "8 Simple Rules" Co-Star
Despite having filmed her last scene for the series almost ten years ago, Kaley Cuoco maintains a great relationship with her former 8 Simple Rules co-star Amy Davidson and has indeed stated that she considers her to be her best friend. Although Cuoco is actually younger than Davidson by six years, she actually played her older sister in the ABC sitcom. The pair are often seen together and Davidson accompanied Cuoco on her bachelorette party prior to her marriage to Ryan Sweeting. Since appearing in 8 Simple Rules, Davidson has gone on to further her acting career with roles in shows like Malcolm in the Middle, Criminal Minds, CSI, Ghost Whisperer, Tia and Tamera, House and Bones.