5. Irene Adler (Sherlock)
Despite the name, Kings Landing isn't a just man's world. With a strong cast of female characters, Game of Thrones has proven that women are just as capable of playing the game as men. Our pick for most likely female to succeed in King's Landing is the woman who very nearly stole Sherlock Holmes' heart. A thief, a genius a ... dominatrix? Yes sex plays a strong part in Game of Thrones (as if you didn't know!) and Irene Adler knows how to use her sexuality to influence even the sharpest minds. A partnership with Littlefinger would make Adler one of the most dangerous women in all of Westeros, because knowledge is power and the best place to gain knowledge of someone is beneath the sheets. Of course we all saw what happened to Ros when she tried getting involved in the game, but Irene Adler is far more intelligent and cunning to get trapped in a bedroom with Joffrey Baratheon. She knows how to use peoples secrets to her advantage and she knows how to avoid or even seduce her enemies. Would she even be interested in the Throne? With or without it she'd still be the most powerful woman in Kings Landing.