So, bet you've often wondered if a naked, unarmed Doctor Doom could take out a lion, right? Sure you have. Well, in the year 2000's DOOM mini-series, whether or not the villain could do that was answered quite emphatically. Doom was in an alternate version of Earth, created by Franklin Richards, that was essentially identical the the original Earth. He was on that Earth's African continent, as naked as the day he was born, when a male lion attacked him. Doom, displaying skill many readers were unaware he possessed up until that point, landed an intentional precision blow on the beast where its brainstem met its spine and rendered it completely unconscious in a single blow. Highly impressive.
