As a hero who got his powers through the traumatic experience of being bitten by a radioactive spider, it makes perfect sense that Spider-Man's enemies also require wild backstories and strange powers in order to go toe-to-toe with the beloved arachnid prince.
And in this regard, Spider-Man's rogues' gallery doesn't disappoint. In fact, the various villains go above and beyond even the spookiest expectations, creating a collection of characters who could legitimately give you nightmares if you read their comics too early.
While it is slightly unnerving to have so many disturbing bad guys against one lone webswinger, it really does make Peter seem like a braver hero. After all, when you see one hero take down a man made out of bees, a zombie demon who can control centipedes, and a drug-dealing cartel of werewolves, you know he's the real deal.
Although they vary from being just gross to being downright horrific, it's always an interesting time to see these villains appear in any story - generally because they take it from being a regular superhero comic, to being a straight up horror story.