On the whole, most weird aspects in comics can be ignored. A weird line or possible plot hole isn't the end of the world, and when the majority of the experience is good, there isn't a lot of reason to focus on the bad.
But sometimes, aspects of a comic are simply too distracting to ignore. While this can often be because of flaws in the issue - like problems with anatomy, or misuse of the medium itself - it's not exclusively bad things that can prove distracting. Often things that are arguably more funny than annoying can still jar your experience, because the level of surreality that some series bring is hard not to focus on.
In a world where countless folk can fly and shooting laser beams from your eyes is only a mid-level power, it's surprising that seeing a celebrity or a bit of genitalia can still shock us every now and then.
But in a way that's the magic of the medium - when you're not engrossed in the comic itself, you can at least be engrossed in seeing the Hulk star in an ad for Hostess cakes.