15 Greatest Marvel Comic Book Villains Of All Time

12. Doctor Octopus

He's always been one of Spider-Man's most iconic villains, but it wasn't until Doctor Octopus discovered he was dying as a result from all the blows to the head he's received at the hands of the wall-crawler that he truly become one of the hero's greatest foes. It was then that he enacted a plan to steal Spider-Man's body, and he succeeded too in one of the most shocking Marvel moments in recent memory.

Despite attempting to become a hero, Doc Ock caused a significant amount of damage to the life of Peter Parker and ultimately gave him back his body when he realised he couldn't protect New York anywhere near as well as his enemy. However, his conciousness is still out there and plotting against Spidey, and it remains to be see whether he'll return as Doctor Octopus or attempt to once again steal Spider-Man's body.