15 Greatest Marvel Comic Book Villains Of All Time

11. Thanos

Thanos' quest for the Infinity Gauntlet has factored into pretty much every single one of his appearances, and the heroes of the Marvel Universe live in constant fear about what could happen when he finally gets his hands on that ancient weapon (the one time he did, he tampered with reality and killed pretty much every single Avenger, so that gives you an idea of just how dangerous he would be if it came into his possession for more than a few minutes).

With The Mad Titan expected to play a key role in the upcoming Civil War II comic and the Avengers: Infinity War movies, his profile looks set to increase in a major way over the next few years, and that means he'll no doubt have yet another event story based solely around his evil schemes before too long.