20 Greatest Spider-Man Villains Ever
13. Chameleon
Chameleon was actually the first supervillain that Spider-Man ever fought, all the way back in Amazing Spider-Man #1. In that issue, the Russian master of disguise used his skills to commit a series of crimes while disguised as Spidey. He's been a mainstay of Peter Parker's rogues gallery ever since.
Dimitri Smerdyakov's most ambitious plan though was when he teamed up with Harry Osborn, helping him construct robotic duplicates of Peter's parents in order to drive him towards a mental breakdown.
A lot of Chameleon's plans have involved similar psychological tricks, trying to drive Spider-Man insane. He has also commit numerous more traditional crimes, often partnering with his half-brother Kraven.