8 Worst Things Doc Ock Has Ever Done To Spider-Man

7. Everything He Did In Spider-Man PS4

Now this may technically not be a comic book moment in the most literal sense, but how could anyone possibly ignore the climax to Insomniac Games' Spider-Man?

The studio opted to fashion a universe of their own when bringing the wall-crawler to current-gen systems, and it worked a treat. They told a brand-new Spidey story, replete with commentary on how Peter Parker has grown up over the years, and wrapped it up with a neat, little devastating blow that left gamers reaching for the nearest box of tissues.

What Insomniac's game did so well (at least, as far as storytelling is concerned), is that it tapped into the tragedy of Otto Octavius' fall. Much like in Sam Raimi's Spider-Man 2, the studio opted to weave Peter's story directly into Otto's origins, going to great lengths to illustrate Spidey's admiration for Octavius, as well as his ignorance in failing to alert to his mentor's mental decline.

This is what makes Otto's inevitable downfall so downright heartbreaking, as players are left powerless to avert disaster. Unfortunately for everyone else, when Ock does take on his new, villainous persona, he unleashes a bioweapon on NYC that leaves thousands dead, including Aunt May herself. It was a moment no one saw coming, and easily made for one of Otto's most egregious offences.