What Happened To Everyone Who Killed Spider-Man?
2. Green Goblin
What sort of Spider-Man list would be complete without mention of the Green Goblin?
Throughout so many of Peter Parker's most traumatic moments, Norman Osborn has been front-and-centre with the best view in the house. And that was very much the case in the aptly-named Death of Spider-Man arc from the realm of Ultimate Spider-Man.
There, the Ultimate take on Parker died while saving his nearest and dearest, as a collection of injuries tragically took their toll - and leading the charge in all of this was Osborn.
Earlier in that story, Peter had taken a literal bullet for Captain America after Frank Castle had the Sentinel of Liberty in his crosshairs. Then, in this weakened state, Spidey rushed home to protect Aunt May after realising that a Goblin-led group of rogues with nefarious intentions were heading for the Parker residence.
In one of the most hard hitting moments in Marvel Comics history, this battle ends with Spider-Man dying. Like, for real. Going out like the quintessential hero, Peter takes down his rivals - including killing Norman! - protects May, succumbs to his wounds, then gets reunited with Uncle Ben in the afterlife.
Not just was the Green Goblin the cause of Parker's demise here, but The Night of the Goblin was a storyline where Osborn again killed Spidey, fatally impaling him with his patented Goblin Glider. The only catch, though, was that it would be the Ben Reilly clone who would bite the bullet here.