10 Alien Invasion Movies Where Humanity Loses

4. Slither (2006)

Annihilation Natalie Portman
Universal Pictures

Before James Gunn was in charge of DC’s film output, making a bonfire of the Snyderverse, he was working on a weird and wonderful array of things, including penning Scooby-Doo and Scooby-Doo 2: Monsters Unleased and writing and directing sci-fi horror Slither.

Notorious for its bath scene (which much of the marketing material for the film was based around), Slilther has the humans of Wheelsy, South Carolina endure a plague of slug-like alien parasites that land with a meteor. They latch onto hosts and infect them, taking over their bodies and absorbing their minds, all in a singular effort for domination.

By the film’s conclusion, the town has been torn apart, with only three survivors, who hobble out of the wreckage in search of help. The presumption is that their ass-kicking efforts have done the slugs in for good, containing and eradicating the alien infestation, but the credits sequence has something to add.

We see a lone cat approaching the remains of the infected and recently deceased Grant Grant (Michael Rooker), taking a nibble and becoming infected itself. And this time there’s nobody there to see it, the spread is free to continue unabated, and more than just this Southern town will be brought to ruin. 

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