19. Doctor Octopus (Spider-Man 2)
Doctor Octopus is something of a glass cannon. His main body is still completely human and therefore vulnerable to all the usual things a human is vulnerable to, but his tentacles more than make up for that by offering a vast degree of protection (keeping opponents at arm's length and deflecting projectiles/bullets etc) and by being incredibly strong and durable themselves. They are strong enough to throw Spider-Man around like a rag doll - and Spider-Man himself is no slouch in the strength department, so that is no mean feat - as well as strong enough to throw cars around. They allow him to move around at great speeds and can tear in to concrete and bricks to enable Doc Oc to climb the walls of buildings.