MCU Phase 4: How And When We'll See Mutants
3. Mutants In Black Widow
Although The Wakanda Files tells us that Hydra chose to experiment on Sokovians due to their genetics, it doesn't look like they were having much luck considering how only the Maximoff twins survived. It is far more likely that the unstable political climate of the country made it easier for Hydra to find volunteers, with the Sokovia facility being but one of many. Mutants do come in all shapes, sizes, and nationalities, and it's not like Sokovia had something life-changing in their drinking water.
This 'many facilities' theory is also backed up by what we've come to know about Hydra. With the amount of planning that went into the takeover of SHIELD, it wouldn't be a stretch to think that Hydra would have spread their research into mutant-kind throughout the world.
This strategy would have prevented a singular assault by the Avengers, as we saw in Age of Ultron, setting the organization back decades. And with the number of different organizations we see in the Marvel Universe, ranging from the Essex Corporation to SHIELD, who's to say that it's only Hydra hiding some research. We're yet to find out what Project E.X.O.D.U.S. is, after all.
Regardless of who runs these facilities, there's no doubt that they present the opportunity to introduce some amazing mutants. The prison we see Red Guardian bust out of in the Black Widow trailer could be a great example of this.
Since the facility was strong enough to keep him under lock and key, who's to say it wasn't strong enough to hold another Russian like Piotr Nikolayevich Rasputin, who you might know better as Colossus. That explosive exit did look a bit intense for what Red Guardian is capable of, which makes me believe that Black Widow will be the first Phase 4 movie to get its mutant on.