10 Hardest Bosses In Resident Evil History
4. Wesker - Resident Evil 5
Say what you will about Resident Evil 5, but the truth is - it's a pretty great game.
The diverse enemy types, ridiculous set-piece battles, and incredible roster of boss monsters make it one of the most enjoyable games in the series. Plus, it gave fans a chance to finally lay some serious smackdown on bastard-man extraordinaire: Albert Wesker.
Most encounters with him across the game's meaty campaign pose a significant challenge, but it's the final battle inside a volcano that really pushed players to the limit. Not only does he deal tremendous damage if you allow him to get close enough, but more often than not, players would have expended most of their ammo in the preceding fight, leaving them with little-to-no hope of finishing the job.
This would mean having to replay earlier levels to amass enough ammo to jump back into the final battle, making the whole thing become an exercise in tedium.
The lack of ammo situation aside, those who decided to play the game solo automatically found themselves at a disadvantage, as Sheva's very wonky AI is not suited to this battle, adding an extra layer of challenge to what is an already grueling affair.