7. Amnesia
Here's another genre that's just been done to death, and moreover, because of the nature of the set-up, we're inclined to smell a rat almost from the very beginning. Whether it's Fahrenheit, Bioshock, Bayonetta, Prototype, Alone in the Dark and so on, an amnesiac protagonist creates an unreliable narrator from the outset, such that we're not likely to believe their memories or their perspective. Though in its earlier incarnations this has resulted in some impressive twists and turns, we're now at a point in gaming that we can see these things coming a mile off; it's a contrived way to lead the player one way and then show them another, but even the most dense player is likely to start sniffing out clues mid-game, presuming the game isn't cheap enough to withhold them from you. What we need is a game to really do something different with the plot, hewing away from the survival horror narratives we're so tired of, and try something scientific with it, perhaps an Inception-esque examination of our memories somehow. Just a suggestion...