The newest entry on the list might also be one of the most terrifying - it's just that nobody's played enough of Alien: Isolation yet to really decided if its eponymous enemy deserves a place in the upper echelons of terrifying, unkillable video game villains. What everybody does seem to agree on is that the title manages to recreate the tone of the first Alien film in a way that none of the myriad Alien games have yet managed, as the player takes on the role of Amanda Ripley (daughter of Sigourney Weaver's Ellen from the movies), who becomes trapped on a space station with the iconic monster. The player's only defence is to hide, scare it off with fire, distract it with a noisemaker, or initiate a game-breaking glitch which shoots them and the alien out into the vacuum of space. Which, to be honest, most people would probably take over another pants-browning moment of the monster descending from the air vents above you, dragging you up and punching a whole in your chest with its mouth-within-a-mouth.
Tom Baker is the Comics Editor at WhatCulture! He's heard all the Doctor Who jokes, but not many about Randall and Hopkirk. He also blogs at http://communibearsilostate.wordpress.com/