10 Video Game Bosses You Didn't Realize Can Be Killed Instantly

The vast number of items and the way in which the player can combine them together are what make The Binding of Isaac such a highly replayable title. However, it turns out that in order to defeat the final boss of the game, Isaac's mom, you only really need one item. The one and only Bible

Generally speaking, the Bible is a pretty decent item to use in most of your runs. It allows you to fly in rooms, plus it's also part of two transformation sets. This said, its main purpose is to help you defeat Mom with one click of a button.

As soon as you enter the final battle room with Mom, simply activating the Bible will immediately kill her. What's better is that you can use it several times in your run, so even if you activated it on Mom's leg, you can still use it on her heart and even the variant bosses on the Gehenna and Mausoleum floors.

Not bad for a millennia-old book.